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ey0017.3-2 | Thyroid hormone action | ESPEYB17

3.2. Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone

SM Praestholm , MS Siersbaek , R Nielsen , X Zhu , A Hollenberg , SY Cheng , L Grontved

To read the full abstract: PLoS Genet. 2020;16:e1008770.Præstholm et al. quantified by a genomics approach histone H3 acetylation an epigenetic mark for DNase accessible chromatin at thyroid hormone target gene enhancers to challenge the current model of genome binding action of T3 (type 1 action of thyroid hormone receptors (TR)) [1]. For this, they investigated genome-wide the liver of WT mice at hypothyroid and hyp...

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ey0015.3-4 | Mechanisms of the year | ESPEYB15

3.4 Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

GS Hones , H Rakov , J Logan , XH Liao , E Werbenko , AS Pollard , SM Praestholm , MS Siersbaek , E Rijntjes , J Gassen , S Latteyer , K Engels , KH Strucksberg , P Kleinbongard , D Zwanziger , J Rozman , V Gailus-Durner , H Fuchs , M Hrabe de Angelis , L Klein-Hitpass , J Kohrle , DL Armstrong , L Grontved , JHD Bassett , GR Williams , S Refetoff , D Fuhrer , LC Moeller

To read the full abstract: Proc Natl Acad Sci U S A 2017;114:E11323-E11332The mechanism of thyroid hormone (TH) action is classically attributed to thyroid hormone receptor (THR) binding to thyroid hormone responsive elements (TRE) in promotors of target genes, directly controlling gene expression in target tissues. Thus, THRs alpha (TRa) and beta (TRb) function as TH dependent transcription ...

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ESPE Yearbook of Paediatric Endocrinology

3.2. Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone

3.4 Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

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